The RENO experiment reports more precisely measured values of $theta_{13}$ and $|Delta m_{ee}^2|$ using $sim$2,200 live days of data. The amplitude and frequency of reactor electron antineutrino ($overline{ u}_e$) oscillation are measured by comparing the prompt signal spectra obtained from two identical near and far detectors. In the period between August 2011 and February 2018, the far (near) detector observed 103,212 (850,666) electron antineutrino candidate events with a background fraction of 4.7% (2.0%). A clear energy and baseline dependent disappearance of reactor $overline{ u}_e$ is observed in the deficit of the measured number of $overline{ u}_e$. Based on the measured far-to-near ratio of prompt spectra, we obtain $sin^2 2 theta_{13} = 0.0896 pm 0.0048({rm stat}) pm 0.0048({rm syst})$ and $|Delta m_{ee}^2| =[2.68 pm 0.12({rm stat}) pm 0.07({rm syst})]times 10^{-3}$~eV$^2$.
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