We report the discovery of the ultra-luminous QSO SMSS~J215728.21-360215.1 with magnitude $z=16.9$ and W4$=7.42$ at redshift 4.75. Given absolute magnitudes of $M_{145,rm AB}=-29.3$, $M_{300,rm AB}=-30.12$ and $log L_{rm bol}/L_{rm bol,odot} = 14.84$, it is the QSO with the highest unlensed UV-optical luminosity currently known in the Universe. It was found by combining proper-motion data from Gaia DR2 with photometry from SkyMapper DR1 and the Wide-field Infrared Survey Explorer (WISE). In the Gaia database it is an isolated single source and thus unlikely to be strongly gravitationally lensed. It is also unlikely to be a beamed source as it is not discovered in the radio domain by either NVSS or SUMSS. It is classed as a weak-emission-line QSO and possesses broad absorption line features. A lightcurve from ATLAS spanning the time from October 2015 to December 2017 shows little sign of variability.