No Arabic abstract
We discuss the flow field and propulsion velocity of active droplets, which are driven by body forces residing on a rigid gel. The latter is modelled as a porous medium which gives rise to permeation forces. In the simplest model, the Brinkman equation, the porous medium is characterised by a single length scale $ell$ --the square root of the permeability. We compute the flow fields inside and outside of the droplet as well as the energy dissipation as a function of $ell$. We furthermore show that there are optimal gel fractions, giving rise to maximal linear and rotational velocities. In the limit $elltoinfty$, corresponding to a very dilute gel, we recover Stokes flow. The opposite limit, $ellto 0$, corresponding to a space filling gel, is singular and not equivalent to Darcys equation, which cannot account for self-propulsion.
Oscillations of flagella and cilia play an important role in biology, which motivates the idea of functional mimicry as part of bio-inspired applications. Nevertheless, it still remains challenging to drive their artificial counterparts to oscillate via a steady, homogeneous stimulus. Combining theory and simulations, we demonstrate a strategy to achieve this goal by using an elasto-electro-hydrodynamic instability. In particular, we show that applying a uniform DC electric field can produce self-oscillatory motion of a microrobot composed of a dielectric particle and an elastic filament. Upon tuning the electric field and filament elasticity, the microrobot exhibits three distinct behaviors: a stationary state, undulatory swimming and steady spinning, where the swimming behavior stems from an instability emerging through a Hopf bifurcation. Our results imply the feasibility of engineering self-oscillations by leveraging the elasto-viscous response to control the type of bifurcation and the form of instability. We anticipate that our strategy will be useful in a broad range of applications imitating self-oscillatory natural phenomena and biological processes.
We propose two-dimensional organic poly(heptazine imide) (PHI) carbon nitride microparticles as light-driven microswimmers in various ionic and biological media. Their demonstrated high-speed (15-23 $mu$m/s) swimming in multi-component ionic solutions with concentrations up to 1 M and without dedicated fuels is unprecedented, overcoming one of the bottlenecks of previous light-driven microswimmers. Such high ion tolerance is attributed to a favorable interplay between the particles textural and structural nanoporosity and optoionic properties, facilitating ionic interactions in solutions with high salinity. Biocompatibility of the microswimmers is validated by cell viability tests with three different cell types and primary cells. The nanopores of the swimmers are loaded with a model cancer drug, doxorubicin (DOX), in high (185%) loading efficiency without passive release. Controlled drug release is reported in different pH conditions and can be triggered on-demand also by illumination. Light-triggered, boosted release of DOX and its active degradation products is demonstrated in oxygen-poor conditions using the intrinsic, environmentally sensitive and light-induced charge storage properties of PHI, which could enable future theranostic applications in oxygen-deprived tumor regions. These organic PHI microswimmers simultaneously solve the current light-driven microswimmer challenges of high ion tolerance, fuel-free high-speed propulsion in biological media, biocompatibility and controlled on-demand cargo release towards their biomedical, environmental and other potential future applications.
The active Brownian particle (ABP) model describes a swimmer, synthetic or living, whose direction of swimming is a Brownian motion. The swimming is due to a propulsion force, and the fluctuations are typically thermal in origin. We present a 2D model where the fluctuations arise from nonthermal noise in a propelling force acting at a single point, such as that due to a flagellum. We take the overdamped limit and find several modifications to the traditional ABP model. Since the fluctuating force causes a fluctuating torque, the diffusion tensor describing the process has a coupling between translational and rotational degrees of freedom. An anisotropic particle also exhibits a noise-induced induced drift. We show that these effects have measurable consequences for the long-time diffusivity of active particles, in particular adding a contribution that is independent of where the force acts.
We report on a new mode of self-propulsion exhibited by compact drops of active liquids on a substrate which, remarkably, is tractionless, i.e., which imparts no mechanical stress locally on the surface. We show, both analytically and by numerical simulation, that the equations of motion for an active nematic drop possess a simple self-propelling solution, with no traction on the solid surface and in which the direction of motion is controlled by the winding of the nematic director field across the drop height. The physics underlying this mode of motion has the same origins as that giving rise to the zero viscosity observed in bacterial suspensions. This topologically protected tractionless self-propusion provides a robust physical mechanism for efficient cell migration in crowded environments like tissues.
We numerically investigate the morphology and disclination line dynamics of active nematic droplets in three dimensions. Although our model only incorporates the simplest possible form of achiral active stress, active nematic droplets display an unprecedented range of complex morphologies. For extensile activity finger-like protrusions grow at points where disclination lines intersect the droplet surface. For contractile activity, however, the activity field drives cup-shaped droplet invagination, run-and-tumble motion or the formation of surface wrinkles. This diversity of behaviour is explained in terms of an interplay between active anchoring, active flows and the dynamics of the motile dislocation lines. We discuss our findings in the light of biological processes such as morphogenesis, collective cancer invasion and the shape control of biomembranes, suggesting that some biological systems may share the same underlying mechanisms as active nematic droplets.