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Register a new userDirect detection of pixel-level myocardial infarction areas via a deep-learning algorithm
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Added by
Chenchu Xu
Publication date
2017
fields
Informatics Engineering
and research's language is
English
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Accurate detection of the myocardial infarction (MI) area is crucial for early diagnosis planning and follow-up management. In this study, we propose an end-to-end deep-learning algorithm framework (OF-RNN ) to accurately detect the MI area at the pixel level. Our OF-RNN consists of three different function layers: the heart localization layers, which can accurately and automatically crop the region-of-interest (ROI) sequences, including the left ventricle, using the whole cardiac magnetic resonance image sequences; the motion statistical layers, which are used to build a time-series architecture to capture two types of motion features (at the pixel-level) by integrating the local motion features generated by long short-term memory-recurrent neural networks and the global motion features generated by deep optical flows from the whole ROI sequence, which can effectively characterize myocardial physiologic function; and the fully connected discriminate layers, which use stacked auto-encoders to further learn these features, and they use a softmax classifier to build the correspondences from the motion features to the tissue identities (infarction or not) for each pixel. Through the seamless connection of each layer, our OF-RNN can obtain the area, position, and shape of the MI for each patient. Our proposed framework yielded an overall classification accuracy of 94.35% at the pixel level, from 114 clinical subjects. These results indicate the potential of our proposed method in aiding standardized MI assessments.
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Myocardial infarction (MI), or commonly known as heart attack, is a life-threatening health problem worldwide from which 32.4 million people suffer each year. Early diagnosis and treatment of MI are crucial to prevent further heart tissue damages or death. The earliest and most reliable sign of ischemia is regional wall motion abnormality (RWMA) of the affected part of the ventricular muscle. Echocardiography can easily, inexpensively, and non-invasively exhibit the RWMA. In this article, we introduce a three-phase approach for early MI detection in low-quality echocardiography: 1) segmentation of the entire left ventricle (LV) wall using a state-of-the-art deep learning model, 2) analysis of the segmented LV wall by feature engineering, and 3) early MI detection. The main contributions of this study are highly accurate segmentation of the LV wall from low-quality echocardiography, pseudo labeling approach for ground-truth formation of the unannotated LV wall, and the first public echocardiographic dataset (HMC-QU)* for MI detection. Furthermore, the outputs of the proposed approach can significantly help cardiologists for a better assessment of the LV wall characteristics. The proposed approach has achieved 95.72% sensitivity and 99.58% specificity for the LV wall segmentation, and 85.97% sensitivity, 74.03% specificity, and 86.85% precision for MI detection on the HMC-QU dataset. *The benchmark HMC-QU dataset is publicly shared at the repository https://www.kaggle.com/aysendegerli/hmcqu-dataset
Echocardiogram (echo) is the earliest and the primary tool for identifying regional wall motion abnormalities (RWMA) in order to diagnose myocardial infarction (MI) or commonly known as heart attack. This paper proposes a novel approach, Active Polynomials, which can accurately and robustly estimate the global motion of the Left Ventricular (LV) wall from any echo in a robust and accurate way. The proposed algorithm quantifies the true wall motion occurring in LV wall segments so as to assist cardiologists diagnose early signs of an acute MI. It further enables medical experts to gain an enhanced visualization capability of echo images through color-coded segments along with their maximum motion displacement plots helping them to better assess wall motion and LV Ejection-Fraction (LVEF). The outputs of the method can further help echo-technicians to assess and improve the quality of the echocardiogram recording. A major contribution of this study is the first public echo database collection composed by physicians at the Hamad Medical Corporation Hospital in Qatar. The so-called HMC-QU database will serve as the benchmark for the forthcoming relevant studies. The results over the HMC-QU dataset show that the proposed approach can achieve high accuracy, sensitivity and precision in MI detection even though the echo quality is quite poor, and the temporal resolution is low.
Myocardial Infarction (MI) has the highest mortality of all cardiovascular diseases (CVDs). Detection of MI and information regarding its occurrence-time in particular, would enable timely interventions that may improve patient outcomes, thereby reducing the global rise in CVD deaths. Electrocardiogram (ECG) recordings are currently used to screen MI patients. However, manual inspection of ECGs is time-consuming and prone to subjective bias. Machine learning methods have been adopted for automated ECG diagnosis, but most approaches require extraction of ECG beats or consider leads independently of one another. We propose an end-to-end deep learning approach, DeepMI, to classify MI from normal cases as well as identifying the time-occurrence of MI (defined as acute, recent and old), using a collection of fusion strategies on 12 ECG leads at data-, feature-, and decision-level. In order to minimise computational overhead, we employ transfer learning using existing computer vision networks. Moreover, we use recurrent neural networks to encode the longitudinal information inherent in ECGs. We validated DeepMI on a dataset collected from 17,381 patients, in which over 323,000 samples were extracted per ECG lead. We were able to classify normal cases as well as acute, recent and old onset cases of MI, with AUROCs of 96.7%, 82.9%, 68.6% and 73.8%, respectively. We have demonstrated a multi-lead fusion approach to detect the presence and occurrence-time of MI. Our end-to-end framework provides flexibility for different levels of multi-lead ECG fusion and performs feature extraction via transfer learning.
Computer vision techniques enable automated detection of sky pixels in outdoor imagery. In urban climate, sky detection is an important first step in gathering information about urban morphology and sky view factors. However, obtaining accurate results remains challenging and becomes even more complex using imagery captured under a variety of lighting and weather conditions. To address this problem, we present a new sky pixel detection system demonstrated to produce accurate results using a wide range of outdoor imagery types. Images are processed using a selection of mean-shift segmentation, K-means clustering, and Sobel filters to mark sky pixels in the scene. The algorithm for a specific image is chosen by a convolutional neural network, trained with 25,000 images from the Skyfinder data set, reaching 82% accuracy for the top three classes. This selection step allows the sky marking to follow an adaptive process and to use different techniques and parameters to best suit a particular image. An evaluation of fourteen different techniques and parameter sets shows that no single technique can perform with high accuracy across varied Skyfinder and Google Street View data sets. However, by using our adaptive process, large increases in accuracy are observed. The resulting system is shown to perform better than other published techniques.
Domain adaptation of visual detectors is a critical challenge, yet existing methods have overlooked pixel appearance transformations, focusing instead on bootstrapping and/or domain confusion losses. We propose a Semantic Pixel-Level Adaptation Transform (SPLAT) approach to detector adaptation that efficiently generates cross-domain image pairs. Our model uses aligned-pair and/or pseudo-label losses to adapt an object detector to the target domain, and can learn transformations with or without densely labeled data in the source (e.g. semantic segmentation annotations). Without dense labels, as is the case when only detection labels are available in the source, transformations are learned using CycleGAN alignment. Otherwise, when dense labels are available we introduce a more efficient cycle-free method, which exploits pixel-level semantic labels to condition the training of the transformation network. The end task is then trained using detection box labels from the source, potentially including labels inferred on unlabeled source data. We show both that pixel-level transforms outperform prior approaches to detector domain adaptation, and that our cycle-free method outperforms prior models for unconstrained cycle-based learning of generic transformations while running 3.8 times faster. Our combined model improves on prior detection baselines by 12.5 mAP adapting from Sim 10K to Cityscapes, recovering over 50% of the missing performance between the unadapted baseline and the labeled-target upper bound.
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