V-QCD is a class of effective holographic models for QCD which fully includes the backreaction of quarks to gluon dynamics. The physics of the theta-angle and the axial anomaly can be consistently included in these models. We analyze their phase diagrams over ranges of values of the quark mass, N_f/N_c, and theta, computing observables such as the topological susceptibility and the meson masses. At small quark mass, where effective chiral Lagrangians are reliable, they agree with the predictions of V-QCD.