In some extensions of the Standard Model, Yukawa couplings of the physical Higgs boson can be deviated from those in the Standard Model. We study a possibility whether or not such anomalous Yukawa couplings are consistent with the LHC Run 1 data. It is found that sizable deviations of top and bottom (and tau) Yukawa couplings from the Standard Model predictions can nicely fit the data. New physics beyond the Standard Model can be revealed through more precise measurements of such anomalous Yukawa couplings at the LHC Run 2 in the near future. We also discuss a simple setup which can leads to anomalous Yukawa couplings.