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Register a new userAnalysis of a diffuse interface model of multispecies tumor growth
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We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods Biomed. Eng., 30 (2014), 726-754]. In this new approach sharp interfaces are replaced by narrow transition layers arising due to adhesive forces among the cell species. Hence, a continuum thermodynamically consistent model is introduced. The resulting PDE system couples four different types of equations: a Cahn-Hilliard type equation for the tumor cells (which include proliferating and dead cells), a Darcy law for the tissue velocity field, whose divergence may be different from 0 and depend on the other variables, a transport equation for the proliferating (viable) tumor cells, and a quasi-static reaction diffusion equation for the nutrient concentration. We establish existence of weak solutions for the PDE system coupled with suitable initial and boundary conditions. In particular, the proliferation function at the boundary is supposed to be nonnegative on the set where the velocity ${bf u}$ satisfies ${bf u}cdot u>0$, where $ u$ is the outer normal to the boundary of the domain. We also study a singular limit as the diffuse interface coefficient tends to zero.
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We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $varphi$ nonlinearly coupled with a reaction-diffusion equation for $psi$, which represents the nutrient-rich extracellular water volume fraction. The coupling is expressed through a suitable proliferation function $p(varphi)$ multiplied by the differences of the chemical potentials for $varphi$ and $psi$. The system is equipped with no-flux boundary conditions which entails the conservation of the total mass, that is, the spatial average of $varphi+psi$. Here we prove the existence of a weak solution to the associated Cauchy problem, provided that the potential $F$ and $p$ satisfy sufficiently general conditions. Then we show that the weak solution is unique and continuously depends on the initial data, provided that $p$ satisfies slightly stronger growth restrictions. Also, we demonstrate the existence of a strong solution and that any weak solution regularizes in finite time. Finally, we prove the existence of the global attractor in a phase space characterized by an a priori bounded energy.
In this article, we present a multispecies reaction-advection-diffusion partial differential equation (PDE) coupled with linear elasticity for modeling tumor growth. The model aims to capture the phenomenological features of glioblastoma multiforme observed in magnetic resonance imaging (MRI) scans. These include enhancing and necrotic tumor structures, brain edema and the so called mass effect, that is, the deformation of brain tissue due to the presence of the tumor. The multispecies model accounts for proliferating, invasive and necrotic tumor cells as well as a simple model for nutrition consumption and tumor-induced brain edema. The coupling of the model with linear elasticity equations with variable coefficients allows us to capture the mechanical deformations due to the tumor growth on surrounding tissues. We present the overall formulation along with a novel operator-splitting scheme with components that include linearly-implicit preconditioned elliptic solvers, and semi-Lagrangian method for advection. Also, we present results showing simulated MRI images which highlight the capability of our method to capture the overall structure of glioblastomas in MRIs.
We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type equation for the tumor phase coupled with a reaction-diffusion equation for the nutrient concentration. We prove that, under physically motivated assumptions on parameters and data, the corresponding initial-boundary value problem generates a dissipative dynamical system that admits the global attractor in a proper phase space.
Both compressible and incompressible porous medium models are used in the literature to describe the mechanical properties of living tissues. These two classes of models can be related using a stiff pressure law. In the incompressible limit, the compressible model generates a free boundary problem of Hele-Shaw type where incompressibility holds in the saturated phase. Here we consider the case with a nutrient. Then, a badly coupled system of equations describes the cell density number and the nutrient concentration. For that reason, the derivation of the free boundary (incompressible) limit was an open problem, in particular a difficulty is to establish the so-called complementarity relation which allows to recover the pressure using an elliptic equation. To establish the limit, we use two new ideas. The first idea, also used recently for related problems, is to extend the usual Aronson-Benilan estimates in $L^infty$ to an $L^2$ setting. The second idea is to derive a sharp uniform $L^4$ estimate on the pressure gradient, independently of space dimension.
We study a diffuse interface model describing the motion of two viscous fluids driven by the surface tension in a Hele-Shaw cell. The full system consists of the Cahn-Hilliard equation coupled with the Darcys law. We address the physically relevant case in which the two fluids have different viscosities (unmatched viscosities case) and the free energy density is the logarithmic Helmholtz potential. In dimension two we prove the uniqueness of weak solutions under a regularity criterion, and the existence and uniqueness of global strong solutions. In dimension three we show the existence and uniqueness of strong solutions, which are local in time for large data or global in time for appropriate small data. These results extend the analysis obtained in the matched viscosities case by Giorgini, Grasselli and Wu (Ann. Inst. H. Poincar{e} Anal. Non Lin{e}aire 35 (2018), 318-360). Furthermore, we prove the uniqueness of weak solutions in dimension two by taking the well-known polynomial approximation of the logarithmic potential.
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