Stellar conditions leading to a possible semi-convective mixing are discussed in three relevant cases: (1) low mass MS stars in which the CNO cycle takes progressively the lead over the PP chain due to the increase in temperature as core hydrogen burning proceeds, (2) massive MS stars which experience a large contri- bution of the radiation pressure to the total pressure and (3) core helium burning stars for which the production of carbon in the core increases the opacity. A short discussion of semi-convection in terms of instability of non radial modes follows.