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Register a new userA Bottom-up Approach for Pancreas Segmentation using Cascaded Superpixels and (Deep) Image Patch Labeling
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Added by
Le Lu
Publication date
2015
fields
Informatics Engineering
and research's language is
English
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Robust automated organ segmentation is a prerequisite for computer-aided diagnosis (CAD), quantitative imaging analysis and surgical assistance. For high-variability organs such as the pancreas, previous approaches report undesirably low accuracies. We present a bottom-up approach for pancreas segmentation in abdominal CT scans that is based on a hierarchy of information propagation by classifying image patches at different resolutions; and cascading superpixels. There are four stages: 1) decomposing CT slice images as a set of disjoint boundary-preserving superpixels; 2) computing pancreas class probability maps via dense patch labeling; 3) classifying superpixels by pooling both intensity and probability features to form empirical statistics in cascaded random forest frameworks; and 4) simple connectivity based post-processing. The dense image patch labeling are conducted by: efficient random forest classifier on image histogram, location and texture features; and more expensive (but with better specificity) deep convolutional neural network classification on larger image windows (with more spatial contexts). Evaluation of the approach is performed on a database of 80 manually segmented CT volumes in six-fold cross-validation (CV). Our achieved results are comparable, or better than the state-of-the-art methods (evaluated by leave-one-patient-out), with Dice 70.7% and Jaccard 57.9%. The computational efficiency has been drastically improved in the order of 6~8 minutes, comparing with others of ~10 hours per case. Finally, we implement a multi-atlas label fusion (MALF) approach for pancreas segmentation using the same datasets. Under six-fold CV, our bottom-up segmentation method significantly outperforms its MALF counterpart: (70.7 +/- 13.0%) versus (52.5 +/- 20.8%) in Dice. Deep CNN patch labeling confidences offer more numerical stability, reflected by smaller standard deviations.
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Superpixel algorithms are a common pre-processing step for computer vision algorithms such as segmentation, object tracking and localization. Many superpixel methods only rely on colors features for segmentation, limiting performance in low-contrast regions and applicability to infrared or medical images where object boundaries have wide appearance variability. We study the inclusion of deep image features in the SLIC superpixel algorithm to exploit higher-level image representations. In addition, we devise a trainable superpixel algorithm, yielding an intermediate domain-specific image representation that can be applied to different tasks. A clustering-based superpixel algorithm is transformed into a pixel-wise classification task and superpixel training data is derived from semantic segmentation datasets. Our results demonstrate that this approach is able to improve superpixel quality consistently.
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