We report the magnetoresistance of a charge-density wave (CDW) in $o$-TaS$_3$ whiskers at 4.2 K under a magnetic field up to 5.2 T. An anisotropic negative magnetoresistance is found in the nonlinear regime of current-voltage characteristics. The angle dependence of the magnetoresistance, studied by rotating the magnetic field upon the $c$-axis, exhibited a two-fold symmetry. The magnetoresistance amplitude exhibits maxima when the field is parallel to the $a$-axis, whereas it vanishes to the $b$-axis. The observed anisotropy may come from difference in interchain coupling of adjacent CDWs along the $a$- and $b$-axes. Comparison of the anisotropy to the scanning tunneling microscope image of CDWs allows us to provide a simple picture to explain the magnetoresistance in terms of delocalization of quantum interference of CDWs extending over the $b$-$c$ plane.
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