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Biological measurement beyond the quantum limit

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 Added by Michael Taylor Mr
 Publication date 2012
  fields Physics
and research's language is English




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Quantum noise places a fundamental limit on the per photon sensitivity attainable in optical measurements. This limit is of particular importance in biological measurements, where the optical power must be constrained to avoid damage to the specimen. By using non-classically correlated light, we demonstrated that the quantum limit can be surpassed in biological measurements. Quantum enhanced microrheology was performed within yeast cells by tracking naturally occurring lipid granules with sensitivity 2.4 dB beyond the quantum noise limit. The viscoelastic properties of the cytoplasm could thereby be determined with a 64% improved measurement rate. This demonstration paves the way to apply quantum resources broadly in a biological context.



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The measurement of a quantum system is often performed by encoding its state in a single observable of a light field. The measurement efficiency of this observable can be reduced by loss or excess noise on the way to the detector. Even a textit{quantum-limited} detector that simultaneously measures a second non-commuting observable would double the output noise, therefore limiting the efficiency to $50%$. At microwave frequencies, an ideal measurement efficiency can be achieved by noiselessly amplifying the information-carrying quadrature of the light field, but this has remained an experimental challenge. Indeed, while state-of-the-art Josephson-junction based parametric amplifiers can perform an ideal single-quadrature measurement, they require lossy ferrite circulators in the signal path, drastically decreasing the overall efficiency. In this paper, we present a nonreciprocal parametric amplifier that combines single-quadrature measurement and directionality without the use of strong external magnetic fields. We extract a measurement efficiency of $62_{-9}^{+17} %$ that exceeds the quantum limit and that is not limited by fundamental factors. The amplifier can be readily integrated with superconducting devices, creating a path for ideal measurements of quantum bits and mechanical oscillators.
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We study an electrostatic qubit monitored by a point-contact detector. Projecting an entire qubit-detector wave function on the detector eigenstates we determine the precision limit for the qubit measurements, allowed by quantum mechanics. We found that this quantity is determined by qubit dynamics as well as decoherence, generated by the measurement. Our results show how the quantum precision limit can be improved by a proper design of a measurement procedure.
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