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Biological measurement beyond the quantum limit

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 Added by Michael Taylor Mr
 Publication date 2012
  fields Physics
and research's language is English




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Quantum noise places a fundamental limit on the per photon sensitivity attainable in optical measurements. This limit is of particular importance in biological measurements, where the optical power must be constrained to avoid damage to the specimen. By using non-classically correlated light, we demonstrated that the quantum limit can be surpassed in biological measurements. Quantum enhanced microrheology was performed within yeast cells by tracking naturally occurring lipid granules with sensitivity 2.4 dB beyond the quantum noise limit. The viscoelastic properties of the cytoplasm could thereby be determined with a 64% improved measurement rate. This demonstration paves the way to apply quantum resources broadly in a biological context.



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The measurement of a quantum system is often performed by encoding its state in a single observable of a light field. The measurement efficiency of this observable can be reduced by loss or excess noise on the way to the detector. Even a textit{quantum-limited} detector that simultaneously measures a second non-commuting observable would double the output noise, therefore limiting the efficiency to $50%$. At microwave frequencies, an ideal measurement efficiency can be achieved by noiselessly amplifying the information-carrying quadrature of the light field, but this has remained an experimental challenge. Indeed, while state-of-the-art Josephson-junction based parametric amplifiers can perform an ideal single-quadrature measurement, they require lossy ferrite circulators in the signal path, drastically decreasing the overall efficiency. In this paper, we present a nonreciprocal parametric amplifier that combines single-quadrature measurement and directionality without the use of strong external magnetic fields. We extract a measurement efficiency of $62_{-9}^{+17} %$ that exceeds the quantum limit and that is not limited by fundamental factors. The amplifier can be readily integrated with superconducting devices, creating a path for ideal measurements of quantum bits and mechanical oscillators.
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We study an electrostatic qubit monitored by a point-contact detector. Projecting an entire qubit-detector wave function on the detector eigenstates we determine the precision limit for the qubit measurements, allowed by quantum mechanics. We found that this quantity is determined by qubit dynamics as well as decoherence, generated by the measurement. Our results show how the quantum precision limit can be improved by a proper design of a measurement procedure.
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Under ideal conditions, quantum metrology promises a precision gain over classical techniques scaling quadratically with the number of probe particles. At the same time, no-go results have shown that generic, uncorrelated noise limits the quantum advantage to a constant factor. In frequency estimation scenarios, however, there are exceptions to this rule and, in particular, it has been found that transversal dephasing does allow for a scaling quantum advantage. Yet, it has remained unclear whether such exemptions can be exploited in practical scenarios. Here, we argue that the transversal-noise model applies to the setting of recent magnetometry experiments and show that a scaling advantage can be maintained with one-axis-twisted spin-squeezed states and Ramsey-interferometry-like measurements. This is achieved by exploiting the geometry of the setup that, as we demonstrate, has a strong influence on the achievable quantum enhancement for experimentally feasible parameter settings. When, in addition to the dominant transversal noise, other sources of decoherence are present, the quantum advantage is asymptotically bounded by a constant, but this constant may be significantly improved by exploring the geometry.
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