We present a detailed study of the Circinus Galaxy, investigating its star formation, dust and gas properties both in the inner and outer disk. To achieve this, we obtained high-resolution Spitzer mid-infrared images with the IRAC (3.6, 5.8, 4.5, 8.0 micron) and MIPS (24 and 70 micron) instruments and sensitive HI data from the Australia Telescope Compact Array (ATCA) and the 64-m Parkes telescope. These were supplemented by CO maps from the Swedish-ESO Submillimetre Telescope (SEST). Because Circinus is hidden behind the Galactic Plane, we demonstrate the careful removal of foreground stars as well as large- and small-scale Galactic emission from the Spitzer images. We derive a visual extinction of Av = 2.1 mag from the Spectral Energy Distribution of the Circinus Galaxy and total stellar and gas masses of 9.5 x 10^{10} Msun and 9 x 10^9 Msun, respectively. Using various wavelength calibrations, we find obscured global star formation rates between 3 and 8 Msun yr^{-1}. Star forming regions in the inner spiral arms of Circinus, which are rich in HI, are beautifully unveiled in the Spitzer 8 micron image. The latter is dominated by polycyclic aromatic hydrocarbon (PAH) emission from heated interstellar dust. We find a good correlation between the 8 micron emission in the arms and regions of dense HI gas. The (PAH 8 micron) / 24 micron surface brightness ratio shows significant variations across the disk of Circinus.
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