The preliminary design of the new space gamma-ray telescope GAMMA-400 for the energy range 100 MeV - 3 TeV is presented. The angular resolution of the instrument, 1-2{deg} at E{gamma} ~100 MeV and ~0.01^{circ} at E{gamma} > 100 GeV, its energy resolution ~1% at E{gamma} > 100 GeV, and the proton rejection factor ~10E6 are optimized to address a broad range of science topics, such as search for signatures of dark matter, studies of Galactic and extragalactic gamma-ray sources, Galactic and extragalactic diffuse emission, gamma-ray bursts, as well as high-precision measurements of spectra of cosmic-ray electrons, positrons, and nuclei.
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