We theoretically demonstrate the possibility to observe the macroscopic Zeno effect for nonlinear waveguides with a localized dissipation. We show the existence of stable stationary flows, which are balanced by the losses in the dissipative domain. The macroscopic Zeno effect manifests itself in the non-monotonic dependence of the stationary flow on the strength of the dissipation. In particular, we highlight the importance of the parameters of the dissipation to observe the phenomenon. Our results are applicable to a large variety of systems, including condensates of atoms or quasi-particles and optical waveguides.