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Generalized Isotonic Regression

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 Added by Ronny Luss
 Publication date 2011
and research's language is English




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We present a computational and statistical approach for fitting isotonic models under convex differentiable loss functions. We offer a recursive partitioning algorithm which provably and efficiently solves isotonic regression under any such loss function. Models along the partitioning path are also isotonic and can be viewed as regularized solutions to the problem. Our approach generalizes and subsumes two previous results: the well-known work of Barlow and Brunk (1972) on fitting isotonic regressions subject to specially structured loss functions, and a recursive partitioning algorithm (Spouge et al 2003) for the case of standard (l2-loss) isotonic regression. We demonstrate the advantages of our generalized algorithm on both real and simulated data in two settings: fitting count data using negative Poisson log-likelihood loss, and fitting robust isotonic regression using Hubers loss.



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We consider the online version of the isotonic regression problem. Given a set of linearly ordered points (e.g., on the real line), the learner must predict labels sequentially at adversarially chosen positions and is evaluated by her total squared loss compared against the best isotonic (non-decreasing) function in hindsight. We survey several standard online learning algorithms and show that none of them achieve the optimal regret exponent; in fact, most of them (including Online Gradient Descent, Follow the Leader and Exponential Weights) incur linear regret. We then prove that the Exponential Weights algorithm played over a covering net of isotonic functions has a regret bounded by $Obig(T^{1/3} log^{2/3}(T)big)$ and present a matching $Omega(T^{1/3})$ lower bound on regret. We provide a computationally efficient version of this algorithm. We also analyze the noise-free case, in which the revealed labels are isotonic, and show that the bound can be improved to $O(log T)$ or even to $O(1)$ (when the labels are revealed in isotonic order). Finally, we extend the analysis beyond squared loss and give bounds for entropic loss and absolute loss.
Isotonic regression is a nonparametric approach for fitting monotonic models to data that has been widely studied from both theoretical and practical perspectives. However, this approach encounters computational and statistical overfitting issues in higher dimensions. To address both concerns, we present an algorithm, which we term Isotonic Recursive Partitioning (IRP), for isotonic regression based on recursively partitioning the covariate space through solution of progressively smaller best cut subproblems. This creates a regularized sequence of isotonic models of increasing model complexity that converges to the global isotonic regression solution. The models along the sequence are often more accurate than the unregularized isotonic regression model because of the complexity control they offer. We quantify this complexity control through estimation of degrees of freedom along the path. Success of the regularized models in prediction and IRPs favorable computational properties are demonstrated through a series of simulated and real data experiments. We discuss application of IRP to the problem of searching for gene--gene interactions and epistasis, and demonstrate it on data from genome-wide association studies of three common diseases.
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