We study the first law of thermodynamics in IR modified Hv{o}rava-Lifshitz spacetime. Based on the Bekenstein-Hawking entropy, we obtain the integral formula and the differential formula of the first law of thermodynamics for the Kehagias-Sfetsos black hole by treating $omega$ as a new state parameter and redefining a mass that is just equal to $M_{ADM}$ obtained by Myungcite{YSM2} if we take $alpha=3pi/8$.
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