We examine the effect of the thermal vacuum on the power spectrum of inflation by using the thermal field dynamics. We find that the thermal effect influences the CMB anisotropy at large length scale. After removing the divergence by using the holographic cutoff, we observe that the thermal vacuum explains well the observational CMB result at low multipoles. This shows that the temperature dependent factor should be considered in the study of power spectrum in inflation, especially at large length scale.
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