The interaction of flux qubits with a low frequency tank circuit is studied. It is shown that changes in the state of the interacting qubits influence the effective impedance of the circuit, which is the essence of the so-called impedance measurement technique. The multiphoton resonant excitations in both single flux qubits and pairs of coupled flux qubits are investigated. In particular, we compare our theoretical results with recent spectroscopy measurements, Landau-Zener interferometry, and multiphoton fringes.