The purpose of the study was to assess the role of the head nurses in managing the performance of the nursing staff at Tishreen University Hospital from the point of view of the nursing staff and the head nurses. The sample that have been used was available of the head nurses and the simple randomness of the nursing staff and was composed of 55.5% of head nurses and their number was (30) head nurses And 50% of the nursing staff participating in the Tishreen University Hospital during the application of the research and their number was (300) nurse. An improved tool for gathering information was used based on recent research literatures, and data were collected and analyzed using SPSS version 20. The most important results: The assessment of the role of head nurses in managing staff performance at Tishreen University Hospital in general was in a good level.