Medication errors are the most common medical errors, which may cause complications in patients, nursing staff are the first one who deal with these errors, so the current descriptive study aim to identify the factors leading to the Medication errors at Tishreen University Hospital from the Point of view of 48 nurses working at internal department by using suitable tool for the study object. The study found that the most important factors that lead to medication errors are the inability to read instructions because of the poor doctor's line, Inability to interpret physician order correctly, the Heavy workload and fatigue, tension and Lack of sleep, and interruption and Distract during Work by someone else, inconvenience during work. The study recommended to establishment of educational courses for the nursing staff in the hospital on the subject of the factors causing the Medication errors and ways to prevent their effects, to inform the doctors and nurses working at hospital about the results of this study, put these results in the consideration of policy makers of the hospital to develop rules and strategies that exceed the impact of these factors to include Patient safety, and similar studies in several hospitals to ascertain the results of the study.