Prevention is the key to reduce the incidence of Contrast-induced nephropathy (CIN) and it begins with identification of the high risk patients. Aim: Identifying the different risk factors for CIN . Methods: This is a prospective analytical study that has included 156 patients, all underwent an objective exam, hematochemical measurements. The patiemts were divided into two groups depending on the incidence of CIN defined as an increase in creatinine level equal or more than 25% from baseline values within 48-72 hours after the coronary procedure. Results: Several independent risk factors for CIN were identified: age equal or more 70 year (OR:4.11, P:0.004( , contrast volume more than 200 ml )OR:3.2,P:0.01(, anemia (OR:2.7,P:0.01), urgent cardiac catheterization) OR:3.3,P:0.02(,diabetic nephropathy (OR:4.9,P:0.04). Conclusion: . Increased contrast volume ,urgent cardiac catheterization elderly patients , anemia and diabetic nephropathy are associated with increased risk for CIN.