We decided to carry out this study to highlight the risk factors, clinical presentations and prognosis for AFS in the neonatal care department at Al-Assad University Hospital in Lattakia, and thus reaching conclusions and recommendations that avoid high incidence rates of this lifethreatening condition. The aim of the study was to shed light on the clinical and laboratory characteristics of the AFS when developing the diagnosis and to study its potential risk factors for its occurrence of neonates in the department of neonatal care. The gold standard for diagnosing AFS in our study was the positive results of blood culture by isolating fungal yeasts from all neonates of the study sample.