Human cell simulation

In this study, we present a state-of-art model; we call SYRIA, to simulate the activity of ventricular myocardial cell as an example of simulating a human cell, in which we use the latest mathematical models of cardiac cell. We rely on O'Hara (O'Hara, et al., 2011) for modeling electrical activity, ions hemostasis, and contracting. Our presented model takes into consideration the role of potassium channels KATP, chloride channels, volume regulation channels based on the Kyoto model (A.Takeuchi, 2006), PH regulation channels based on Leem model (Leem, et al., 1999), and the improvement of the values of some variables based on the results of modern experiments, especially concentrations of ions within the mitochondrial and cytoplasm, the values of calcium buffers in the SR, values of the conductance of membrane channels, and concentrations of metabolites in the mitochondria. The previous models have been linked to a mitochondrial model based on Kembro (Kembro, et al., 2013). The SYRIA model is based on the integration and improvement of the best known models in a hierarchical structure that facilitates understanding, monitoring and reuse, we also present models for testing drugs and some external influences. The programming process is done using blocks of M-file and S-function in Simulink. By comparing the results obtained from the simulation with the laboratory results, we observe that computer simulations give results within the normal physiological range .