The research was conducted to study the resistance of Nerium plant which are planting on sides of roads and the cities portals. The research was performed by studying the leaves of Nerium plant, through studying the length and weigh of the leaf, and its area and water content. In addition to studying the wools and hiatus and chlorophyll concentration, and compared the results between the polluted region which is the entry of Banias City, and the control one which is the gardens of Tishreen University. Results showed non significant reduction in length, weight and area of the leaf in the polluted region compared with the control one. It attained (16.2 cm, 0.97 g and 26.3 cm2), respectively in the polluted region. Where it was (17.8 cm, 1.25 g and 27.7 cm2), for control region, respectively. Also, there was no significant differences in water content between the two studied regions. It attained respectively (52.2 and 53.9 %). Our results showed: - That a number of hiatus decreased, whereas the wools increased in the polluted region compared with control region insignificantly. The mean of a number of it was 12 in polluted region, compared with 14 in the control region. - A simple insignificant reduction in the concentration of chlorophyll A in polluted region compared with the control, where it attained (0.93 and 0.98), respectively. The Nerium oleander plant was resistance and tolerance to the air pollution.