With increased attention to regional and spatial planning in the world and the need to pay attention to modern spatial development methods, increased thinking for necessity urban networks as a mechanism for achieving spatial development in small and medium-sized cities, operating alone, has been enhanced by changing the spatial structure of the Territory, raising qualitative and quantitative use, To collect the assets and resources of the cities of the Region that accept participation in potential opportunities and risks. The analytical study was implemented by proposing an urban network in the Greater Damascus Region that examines the nodes and links, and uses the SWOT system to examine opportunities and possibilities, its relationship to the problems and determinants of selecting the best scenario for the proposed urban network examines the effect of applying the urban network concept on changing the spatial structure of the Greater Damascus Region, and propose a workable mechanism at the spatial-sectorial level. The research concludes with a set of conclusions and recommendations that determine the importance of the networking of cities according to their location, which is capable of adapting to the changes taking place in our Syrian cities. In the absence of a future vision for regional development that is appropriate to the current situation, taking into account the economic, social and spatial changes taking place; and which hinder the achievement of the proposed national framework for regional planning in 2010.