Evalution of the results of 3D conformal radiotherapy inT1/T2 of larynx cancer, Experience radiotherapy´department of tishreen university hospital


Abstract in English

Larynx cancer is the most common cancer of the head and neck with the exception of the skin and it accounts for 2% of all cancer diagnoses, its genesis is directly associated with alcohol drinking and smoking, squamous cell carcinoma (SCC) is the most common histological type (95%) of larynx cancer. Aim: The purpose of this study was to evaluate 3D conformal radiotherapy of accelerated system for early larynx cancer and to estimate acute and late toxicity which appear because of irradiated normal tissues around the tumor (thyroid gland, spine cord, ….) and also to evaluate the rate of recurrence and survival. Materials and methods: The study was performed of 44 patients of scc larengeal cancer stage T1/T2, that underwent RT (2015 – 2017), 84% with glottic cancer, the median age was 63 years, all patients were treated 3D conformal RT, Total dose between (60-66) Gy, 2Gy/fraction (5 fractions in week).Our analysis was to evaluate the acute and late toxicity dure and after radiotherapy, and also the rate of recurrence and survival. Results: The most toxicity was dysphagia (42 PTs) 96%, radiodermitis (30 PTs) 70%, the least toxicity was tooth damage. No evidence of late toxicity, the rate of recurrence (11 PTs) 25%, metastases occur in (1 PT). (6/ 41 PTs) 16.4% were dead. Conclusion: Radiotherapy is the important role to control early larynx cancer, and 3DRadiotherapy is giving a large dose to treat the tumor and save the normal tissues around the tumor from effect of radiation, therefor absence the late toxicity.

References used

BRUCHON,Y; BONNETAIN,F; BARILLOT,I; TRUC,G; Conservative treatment of early glottic carcinomas with exclusive radiotherapy Cancer/Radiothérapie, Volume 8, Issue 5, October 2004, Pages 288-296
AMADOA,A.C; BUJOR,A.L;GRILLO,M.G ,3D conformal hypofractionated radical radiotherapy in early glottic cancer a Radiotherapy Department, Hospital de Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal , Medical Faculty of Lisbon, Lisbon University,September–October 2013.Pages 261-264
EITAN MEDINI, M.D ; ALLEN MEDINI, B.A. ; MARKUS GAPANY, M .D ;et al, Radiation therapy in early carcinoma of the glottic larynx T1NOMO, , Volume 36, Issue 5, 1 December 1996, Pages 1211-1213

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