Introduction: Thrombocytopenia is considered to be a common complain of outpatients and hospitalized ones, ranging from asymptomatic to severe death causing hemorrhage. Diagnosing thrombocytopenia depends mainly on study of bone marrow which is an invasive process. Complete Blood Count on automated hematology analyzers is widely used nowadays with no extra cost, and platelets indices are part of the blood profile and less often used in diagnosing thrombocytopenia. Aim of the study: Investigation of a possible relationship between platelets indices (MPV and PDW) and thrombocytopenia etiologies (hypoproductive or hyperdestructive), and determine the sensitivity and specificity of platelets indices in the approach of thrombocytopenia.