Information and communication technology (ICT), Gross capital formation, Openness, and Inflation are frequently well-thought-out as important drivers of economic growth for all countries, and especially for developing countries. This study aims to examine the effect of these factors no economic growth in Syria covering the period from 1995-2012, with main interest of the impact of ICT. To this end, the study utilized annual time series data set over the period 1990 to 2010. Econometric techniques include testing the stationary of data by applying (ADF) test and applying Autoregressive Distributed Lag (ARDL) method of estimation. Moreover, Short run and long run estimates were found . The paper confirms a negative and statistically significant relationship between the economic growth and technology index in the short run, but the relationship becomes positive and statistically significant in the long run. This paper confirms a negative and statistically significant relationship between the economic growth and GFC in the short run, but the relationship becomes positive and statistically significant in the long run, where the relationship between openness and economic growth is positive both in the short and long run, whereas the relationship between the inflation rate and economic growth is negative both in the short and long run.