This study was carried out at Hamah Research Centre during 2014/ 2015 season on Shami goat flock (25 heads) in late pregnancy to determine some indicators of pregnancy toxemia in Shami goat. The blood samples were taken from both groups at different stages of late pregnancy to be used in several biochemistry tests (BHB, NEFA, glucose, total protein, albumin and triglyceride). The blood tests showed a significant increase (p≤0.01- 0.001) in BHB and NEFA, and a significant decrease (p≤0.05) in glucose during 2- 3 weeks antepartum, but one week antepartum for the albumin. But regarding triglyceride it was high (p≤0.05) during 1- 3 weeks antepartum. It was noticed a trend to acidic pH in urine of the tested animals. Also, the acetone was positive (+++) one week before partum. In conclusion, it is important to evaluate some clinical and biochemical parameters, besides acetone and pH estimation in urine for the early diagnosis of risks of pregnancy toxemia in Shami goat’s prior the birth time. This can give time for owners to take some protection procedures.