Background: cancer patients experience large physical and emotional challenges related to side effects of chemotherapy drugs, which make coping and adaptation essential issue for coping with disease. Aim: this study was conducted to identify coping strategies among cancer patients during chemotherapy and its relation with patient's age and gender Methods: data were collected from 150 patients from Tishreen university hospital by using brief coping questionnaire in addition to demographical sheet Results : the results revealed that cancer patients tend to use various coping strategies which are problemfocused and emotional- focused, reflected positive and negative coping. The most used coping strategies were active coping strategy (78.66%), followed by seeking social support for instrumental reasons strategy (76.66%), followed by planning strategy (76%), then focus on and venting of emotions (75.33%), followed by acceptance strategy (70.66%), then seeking social support for emotional reasons (68%), then turning to religion (58%). Also results showed that coping strategies changed according to age and gender changing (p < 0.05) where women tend to use emotional- focused coping strategies while aged patients prefer emotional social support and acceptance. Conclusion: emotional issues for cancer patients during chemotherapy require more concern with ongoing assessment for adaptation and coping strategies, for designing appropriate interventions agreed with coping behaviors which cancer patients demonstrate during treatment.