Asthma exacerbations can be frequent and range in severity from relatively mild to status asthmaticus. While the efficacy of intravenous MgSO4 hasbeen demonstrated, the informations available on its inhaled role still low and conflicting, so the study aim to investigate the effect of thecombinationof MgSO4and salbutamol in the management of acute asthma attack. A randomized clinical trial was conducted on 76 patients, divided into two groups: experimental (40) and control (36) patients. The trial received nebulised salbutamol with magnesium sulphate and control nebulised salbutamol with saline serum 0.9% on three sessions in 20 minutes. Signs of respiratory distress, wheezing, respiratory rate, pulse, Sao2 and PEF were assessed. Magnesium sulphate showed a significant effect in improving respiratory rate, Sao2 and PEF starting from the 20th minute( P <0.05), but did not observe the effect of MgSO4 in improving signs of respiratory distress, pulse and wheezing(P> 0,05), no side effects attributed to magnesium sulphate were observed.Inhaled MgSO4, incombination with salbutamol, appears to have benefits in the treatment of acute asthma attack.