Background: Lidocaine had shown to inhibit neural conduction and antiinflammatory properties. The purpose of this research was to study the effect of using intravenous lidocaine with general anesthesia drugs on opioids and inhaled anesthesics consumption during surgery and the require of analgesics after surgery. Setting: This study was carried out in the department of anesthesia and reanimation at Tishreen University Hospital, Lattakia, Syria during 2017-2018. Type of study: Double-blinded randomized comparative study.