Skin-to-skin contact (SSC) between the mother and her infant immediately postdelivery is an important procedure that must be included in the care given to mother and her infant many health benefits. The mother's desire and reaction towards (SSC) is the decisive factor in the success of this procedure, so the current study aimed to investigate the initial reaction of 200 women towards (SSC) immediately after their vaginal delivery were randomly selected from the obstetric hospital and national children in Lattakia, data were collected using a questionnaire developed for this purpose. The study showed that nearly three-quarters of mothers agreed to have contact with their children in (SSC) and nearly three-quarters of approvals preferred to be covered. The highest rate of response to approvals for contact with their children immediately after birth was the expression of joy in child and then hugging and kissing him. While the highest response of non-approvals for contact with their children immediately Post-Delivery refused to touch the child because they were suffering of pain. The study recommended that every mother in the labor room be investigated for carrying her naked child or swaddled with a blanket immediately after birth, not forcing them to immediately postpartum (SSC), the study recommended to continuing education and training sessions to provide all midwives and nurses working in the labor rooms with information and skills (SSC) for all mothers immediately Post- Delivery, and further research on nurse and midwife information on the importance of prompt (SSC) immediately Post-Delivery.