The aim of this study is to collect more information about Congenital hypothyroidism (CH) in Syria due to it being one of the most common causes of preventable mental retardation if detected at early stage and treatment is preventable, and to the absence of any published statistics regarding it in our country, and to emphasize on the necessity of applying a mandatory newborn screening program for early diagnosis of congenital hypothyroidism to improvement of child’s life, by investigating the adequacy of the clinical determination the physician's experience to get an early diagnosis.