This study aimed at identifying the relationship between the Structural capital and innovation performance in Tishreen University. It applies the theoretical concepts. the researcher relied survey methodology, and distribution the questionnaire to 360 individual of the members of the Teaching Staff in Tishreen University, and then make a Field Study to show this relationship, the main result of this study is that there is a positive significant relationship between the Structural capital and innovation performance. We have provided a summary of the most important results that we have accessed with the presentation of some of the proposals and recommendations to improve the relationship in order to enhance innovation performance to the members of the Teaching Staff in Tishreen University.