This study aimed at identifying the relationship between the human capital and innovation performance in Tishreen University. By Identifying the Impact of each the skill, knowledge, and experience. The researcher relied on the Deductive Approach as a general method. He follows a survey methodology, and he gave a questionnaire to 360 people, they are members of the Teaching Staff in Tishreen University, He also made a field Study to show this relationship, The main result of the study was that there a positive significant relationship between the human capital and innovation performance. We have provided a summary of the main result that have found out is that the possession of Tishreen University of human capital capable to innovation performance (radical and Incremental). With the presentation of some of the proposals and recommendations to improve the relationship including the need to work on the development of skills and knowledge and gain more of it, in order to enhance innovation performance to the members of the Teaching Staff in Tishreen University.