This research aims to produce a diagnosis system for breast cancer by using Neural Network depending on Back Propagation algorithm(BPNN) and Adaptive Neuro Fuzzy Inference System ‘ANFIS’, the both of studies was done using structural features of biopsies in “Wisconson Breast Cancer “data base. In the end a comparison was made between the two studies of malignant- benign classification of breast masses of breast cancer which has accuracy 95,95% with BPNN and 91.9% with ANFIS system, this results can be consider very important if they compared with researches depending on image features that obtained of various devises like mammography, magnetic resonance.