The study aims to evaluate the financial performance of Islamic banks in Syria by using financial ratios during the periods (2009_2015), and study the factors affecting on financial performance of those banks. This was based on studying the relationship between financial performance evaluation as dependent variable measured by (return on assets, return on equity, return on deposits, and earnings per share) and the following independent variables (deposits, investment, liquidity and risk, profitability, and crisis in Syria). The study employed the methods of Panel Data through estimating Pooled Regression and Fixed Effects Models. The study concluded that there is a significant positive relation between the investment and the bank financial performance evaluation. There is a significant negative relation between the profitability and the bank financial performance evaluation. And there is no significant relation between (the deposits, the liquidity and risk, the crises) and the financial performance evaluation in Islamic banks in Syria.