Cleaning denture have the most important point to dentist because it has the most effect in the live of the removable denture and in the health of the mouth tissue , so we must to share between mechanical cleaning with tooth brush and with chemical cleaning to kill the bacteria and candida albican and to remove food depris from the denture surface . there are many disinfection solutions for removable denture so we have to do a research for effect of these solutions on the removable denture which made from Crom Cobalt alloy, and on the candida albican colonization on the denture surface .