The aim of this research is to identified the tectonic evolution of Naher Al-Kabir Al-Shimaly Basin from tectonic subsidence curve witch calculated from Lattakia1 well data. Tectonic subsidence was identified in lower-middle Jurassic en relation of opening of East Mediterranean basin. A subsidence is occurred in Cenomaniane, after a stage of uplift in late Jurassic-lower Cretaceous en relation to fold and erosion known at regional scale.