This study was performed in the faculty of dental medicine –Damascus university. the studied sample contained 30 patients in need for surgical extraction of third inferior molar. A dose of 2 grams of amoxicillin was administered an hour before surgery to 15 patients. The oral health was assessed using plaque index and gingivitis index. 5ml of venous blood was taken pre and post surgery. Blood was then put in special glass bottles and incubated in 37c for five days, then the blood samples were cultured on blood agar and MacConkey's agar and then searched for any bacterial growth bacterimia percentage was 0% before surgery in all study participants, while it was 71.4% with amoxicillin and 42.9% without amoxicillin.