Background and Objective : Bone morphogenic protine-2 (BMP-2) plays an essential role in mesenchymal cells differentiation into osteoblasts، through many intracellular pathways which crosses with tumoral pathways . Oral squamous cell carcinoma is an invasive epithelial neoplasm، counts more than 90% of head and neck malignancies. It is classified into three degrees according to the epithelial cells differentiation. The study aimed to investigate the changes in BMP-2 expression according to the histological degrees of the tumor. Materials and methods : In the present study، BMP-2 expression was compared immunohistochemically among oral squamous cell carcinoma in 27 cases (19 male+8 female) ranging between (22-74) years، mean age of (48) years. Patients have been divided into 3 groups (each contain 9 case) according to the histological grade. Results : By analyzing the statistical results, No significant correlation between BMP-2 expression and the histological grad was observed. The severity of expression was not affected by the tumour degree. Changes in membranous localization and intense cytoplasmic staining were also not observed. Conclusion : according to this study BMP-2 does not represent a prognostic marker for the histological grade of oral squamous cell carcinoma.