The research aims to make a statistical approach to the cases of esophageal atresia by its types and incidence, and to study the surgical treatment outcome and choose the best method of treatment and follow up. The study included 27 newborn patients admitted in the Neonatal Intensive Care Unit at Al-Assad University Hospital and Tishreen University Hospital in Lattakia, due to diagnosis of esophageal atresia or tracheoesophageal fistula, from the beginning of January 2010 until the end of 2015. 14 of patients were males and 13 were females. Gross classification of esophageal atresia was used, type (C) was found in 21 cases, type (A) was found in 4 cases, type (E) was found in 2 cases, while type (B) and (D) were not seen. We studied The clinical symptoms in newborn patients with this malformation, radial and laboratory findings and associated malformations. We used esophageal contrast study insure the diagnosis when needed. With type (C), we did primary anastomosis in 20 cases and cervical esophagostomy with gastrostomy in only 1 case. With type (A), we did esophagostomy with gastrostomy in all cases. With type (E), we closed the fistula with cervical approach in all cases. The survival rate was 70.4%. Spitz classification was used for risk assessment. The incidence of complications included anastomotic leakage 30% and anastomotic stricture 69.2%.