Background : Molluscum contagiosum is one of the commonest cutaneos viral infections in children . Although there is no specific treatment for this infection many therapeutic modalities have been used with different success rates , including curettage, trichloroacetic acid , and cryotherapy . All treatment modalities are associated with substantial pain, tissue destruction, and frequent recurrence. There are other modalities that can be applied by parents and less side effects , such as using tretinoin and KOH . In our study , we compare between KOH which dissolves keratin and penetrate deeply the skin , and tretinoin which damages the viral protein – lipid membrane Objective : To compare the efficacy and side effects of KOH 15% solution with tretinoin 0.05% cream for treatment of molluscum contagiosum . Material and methods : Total 52 patients with molluscum contagiosum were enrolled in this study, from 2013 to 2014 , from Dermatology Department of Al Assad University outpatients, Lattakia .We have designed a questionnaire include personal factors In addition to the tables to compare all of KOH (15%) solution and teritnoian (0.05%) cream in terms of effectiveness in the treatment and side effects. Results : Mail : female ratio was (1.48 : 1) , age onset was higher at first decade (67.3%). The most common involved site was the trunk ( 42.3 %) . Both of the study treatment regimens have advantage over other treatment options as they are locally applicable , less traumatic and painful . Because of these characteristics , they can be easily applicable for the treatment of Molluscum Contagiosum . During the treatment period , using KOH (15%) showed cure rate ( 75%) after two weeks of treatment , while using tretinoin (0.05%) showed cure rate (20.8%) after two weeks, and most of the patients need four weeks and even more Conclusion : The result of both KOH and tretinoin showed good response , well tolerated by children but between the two , KOH showed fast recovery and most lesions were resolved before 4 week . The side effects could be minimized if applied as stated above . On the other hand , tretinoin showed delayed response and even some of lesion extended beyond 4 week but the side effect were less , and hence can be used in recurrent cases.