The present study describes a simple stability-indicating reversed-phase HPLC assay for pentoxifylline in its pharmaceutical dosage forms. Separation of the drug and the degradation products، under stress conditions was successfully achieved on a C18 column utilizing water: MeOH (60:40 v/v)، pumped at a flow rate of 1 ml min-1 with UV detection at 272 nm. The retention time of pentoxifylline was about 14 min. The method was satisfactorily validated with respect to linearity، precision، accuracy and selectivity. The response was linear in the range of 0.6-3.5 μg/ml with R2 0.994. The method was accurate (recovery 100.1%) and precise (RSD < 2%). Detection and quantification limit were 0.2 μg/ml and 0.4 μg/ml respectively. The suggested method was successfully applied for the analysis of pentoxifylline in extended release tablets available in Syrian market.