Synthesis of new compounds for Hetrocyclic (Thiazole, Thiadiazole, Thiazolidine, Azolidinone) containing Fluorine moiety and study of antibacterial activity of prepared compounds
published by Tishreen University
in 2017
in Chemistry
and research's language is
العربية
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Abstract in English
Aseries of Schiff base and their derivative (fluorene) have been synthesized primary
amines was condensed with 2-acetyl fluorene in DMF (dimethyl formamide) in the
presence of conc. HCl acid as catalyst to yield the Schiff base (1). The Schiff base (2,3)
and (4) were prepared from the reaction of Schiff base (1) with 2-hydroxy-5-methyl-1,3-
benzenedicarboxaldehyde and 2,5-dihydroxy benzaldehyde respectively. and The Schiff’s
base (4) was treated with monochloroacetyl choride to give 1- substituted-4(2-fluorenyl)-3-
chloro Azolidine-2-on (5).
References used
Salam. J. J. Titnchi, Fadhil. S. Kamounah, Hanna. S. Abbo, and ole Hammerich, "the synthesis of mano – and diacetyl -, H- fluorenes. Reactivity and selectivity in the lewis acid catalyzed Friedel –Grafts acetylation of, H-fluorine", arkivoc, 2008, Xiii, 91-105
Helmut. G. Alt, Syriac. J. Palackal, "fluorine – coumpounds", United States Patent, USOO, 5, 210, 352A, 1993
Ping Shanlai., (2007)- "Directed Ortho metalation – Boronation Suzuki – Miyaura cross coupling leading to syn thesis of Azafluorenol core liquid crystals". A thesis for the degree of science. Queen's university. Cansda