This Study focused on the lithostratigraphic properties of Mamlaht Al-Kom structure, for evaluating the hydrocarbon potential of this important structure. In order to achieve this goal, the time and depth maps are constructed, through revaluating and interpreting the seismic sections, correlating the drilled wells, and appraising the available well rock samples. The obtained data permit to ensure the hydrocarbon potential of the K.D formation, because of its suitable thickness, presence of cover, and source rock. On the other hand, the entire shape of the structure is not defined accurately as all the exploration wells were drilled along the axis North East – South west. Thus these results should be checked by reinterpreting the available seismic data depending on the geological and lithostratigraphic data, and drill exploration wells on the axis North – South to define the depth and structure of the reservoir reliably.