Preparation some of Phenol ethers which have pharmaceutical applications in green method

Phenol derivatives have been reacted with aryl halides under heterogeneous basic catalyst (Amberlyst-21) using 5 mol% Cu(I) Complex as catalyst, [CuClPPh3]4. The typical reaction has been performed between p-cresol and bromobenzene. This reaction is achieved in o-xylene as solvent. However, the catalyst complex does not dissolve in toluene rather it acts as heterogeneous catalyst. Therefore, it is filtrated at the end of the reaction and reused several times. Accordingly, new compounds were prepared by reacting one of the bromoaryl derivatives with paracetamol. It is anticipated that the synthesized compounds may have pharmaceutical application as non-steroidial anti-inflammatory drugs (NSAIDs).