Preparation some of glycerol aromatic ethers which have pharmaceutical applications in green method


Abstract in English

The Reaction of Glycerol carried out with tow aryl halides under basic conditions (K2CO3) using 5 mol% of Pd(II)Complex as catalyst, Pd(PPh3)2Cl2. The typical reaction has been performed between glycerol and bromobenzene. This reaction is achieved in water as solvent. However, the catalyst complex does not dissolve in aqueous solutions rather it acts as heterogeneous catalyst. Therefore, it is filtrated at the end of the reaction and reused several times. Accordingly, new compound were prepared by reacting glycerol with 1-bromo-2,6-dichlorobenzene. It is anticipated that the synthesized compounds may have pharmaceutical application.

References used

Sutter, M., Silva, E., Duguet, N., Raoul, Y., Métay, E. and Lemaire, M. (2015). Glycerol Ether Synthesis: A Bench Test for Green Chemistry Concepts and Technologies. Chemical Reviews, 115(16), pp.8609-8651
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