The Reaction of Glycerol carried out with tow aryl halides under basic conditions (K2CO3) using 5 mol% of Pd(II)Complex as catalyst, Pd(PPh3)2Cl2. The typical reaction has been performed between glycerol and bromobenzene. This reaction is achieved in water as solvent. However, the catalyst complex does not dissolve in aqueous solutions rather it acts as heterogeneous catalyst. Therefore, it is filtrated at the end of the reaction and reused several times. Accordingly, new compound were prepared by reacting glycerol with 1-bromo-2,6-dichlorobenzene. It is anticipated that the synthesized compounds may have pharmaceutical application.