Oral complications are common in patients with cancer who undergo chemotherapy treatment. Not all patients are at equal risk for developing oral complications. A number of variables have been identified that bear on both the frequency and severity of oral problems associated with therapy. These can be divided into those that are associated with the patient and those that are related to the treatment regimen. In this study we have studied the effect of patient age and gender on the oral complications in group of patients who undergo chemotherapy treatment. We conclude that aging can affect some oral complication chemotherapy like xerostomia and taste changes whereas gender has it effect on pain and oral sence disorders mainly in males.